Xanthomonas oryzae pv. oryzae (Xoo) is assumed to be the oldest and most important disease in rice history including in Malaysia (See photo above). BPH is characterized with wilting of paddy seedlings and/or yellowing or drying of the leaves. Farmers first encountered BPH in 1980s however, over the decade there is no reports of the disease incidence were observed. In the recent years in which the disease re-emerged and reared its ugly head on at least 12,080 ha of rice fields in Peninsular Malaysia (Source: DOA, 2019). Similar to blight disease in which DOA reported about 30 - 50% potential loss of yield due to bacterial leaf blight (BLB) disease infection. The most severe leaf blight disease outbreak in the last 30 years occurred in the paddy field of Sekinchan, Selangor, in 2016 causing 50 - 70% loss of yield. During the outbreak from the report that the farmers had planted the new variety MR284 that was released just a year ago. In 2017 the report shows that there are another type of blight, namely Bacterial Panicle Blast (BPB) caused by Burkholderia glumae showed up at Ache River, Penang and a year later in Kelantan. BPB infected rice plants have upright panicles, florets with darker basal portion of the glumes, and reddish-brown border across the florets. According to MARDI in which for the granaries in various states in Peninsular Malaysia have recorded up to 50% losses due to BPB. As for sheath blight (ShB) or caused by Rhizoctonia solani is the soilborne necrotrophic fungal causative agent that is responsible for yield loss of up to 45%. The symptoms are the formation of lesions on the sheath leading to softness and lodging of the sheath and inhibition of grain filling. Besides blast and blight, the rice plants have always been prone to tungro disease (Penyakit virus merah) that is transmitted by green leafhopper also known as Nephotettix virescens. The disease results from an infection by two distinct viruses, Rice tungro bacilliform virus (RTBV) and Rice tungro spherical virus (RTSV). Although the symptoms of yellow-orange leaf discoloration, plant stunting and reduced yield were recognized since 1934, but its viral nature only came to light in 1965. Despite the significance of tungro disease, very little work has gone into understanding it except for the first genome sequencing of RTBV undertaken in 1999. Annually almost US$1.5 billion is lost worldwide while in Asia about 10% of loss in rice yield had been attributed to this disease.